A new book from Dr Philip McMillan & John McMillan
Everything I study runs back to the lining of your blood vessels.
COVID as an immune-mediated vascular disease. The endothelial dysfunction behind Long COVID. The blood supply to an ageing brain. Each strand of the research arrives at the same thin tissue — and at the one molecule that regulates it. The NO Secrets is the practical, evidence-honest companion to that work.
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The NO Secrets: Nitric Oxide Solutions from Ancient Medicine
Sixteen chapters · Lumienta Limited, London
How the research arrives at this book
1
COVID-19
Proposed in April 2020 as an immune-mediated vascular disease driven by autoimmunity, and developed since across peer-reviewed work.
2
Long COVID
Persistent symptoms that keep pointing back at the endothelium — the single-cell lining of every blood vessel in the body.
3
The ageing brain
Cerebral blood flow and vascular contribution to cognitive decline: the strand of the work behind the dementia keynotes.
4
Nitric oxide
The molecule that governs how those vessels relax and open. Its biology won the Nobel Prize in 1998. The practices that support it are far older.
Sixteen protocols. Sixteen civilizations. One molecule.
Each chapter takes one practice — a food, a way of breathing, a habit — traces it back to the civilization that arrived at it long before anyone could explain why, and then sets out the modern research that finally does.
It is a book about supporting the vascular system, written for people who want the mechanism as well as the instruction.
What makes it different
Every chapter ends with a clinical perspective that argues with the chapter.
- What the evidence genuinely supports — and where it thins out or runs ahead of the story.
- Drug interactions and cautions that a supplement label will never give you.
- Who should be careful, and why.
This is the health book that tells you what doesn’t work. That is an unusual thing for a health book to do, and it is the reason this one exists.
Beetroot
Chapter 1 — and the everyday mistakes that stop it working
Sunlight
Chapter 9 — skin, blood vessels and a route that has nothing to do with vitamin D
Nasal breathing
Chapter 2 — the nitric oxide your sinuses make, and what mouth-breathing switches off
Mouthwash
Chapter 10 — the oral microbiome, and a hygiene habit that can cancel the rest
Cacao
Chapter 4 — the Mesoamericans, and why most chocolate has the benefit processed out
Watermelon
Chapter 11 — the Ancient Egyptians, and an amino acid pathway
Six of the sixteen. The others run from Tibetan breath practice at altitude to Burmese fermented tea.
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If you have not come across the wider work
The research this book sits alongside
I am a physician and researcher. In April 2020 I proposed that severe COVID-19 was primarily an immune-mediated vascular disease driven by autoimmunity — an argument developed since across peer-reviewed papers on immunology, viral persistence and macrophage biology.
That work led outward rather than inward: to Long COVID, to the vascular contribution to cognitive decline, and to international keynote work on dementia mechanisms. The common thread is the endothelium, which is how a researcher in immunology ends up writing about beetroot.
The rest of it — the analysis, the dashboards, the consultations, the courses — lives elsewhere on this site. It is not what this page is for.
Selected peer-reviewed publications
- McMillan et al. (2021) — autoimmunity against ACE-2. Frontiers in Immunology
- McMillan, Turner & Uhal (2024) — gut-related viral persistence in Long COVID. Viruses
- McMillan, Turner & Uhal (2026) — macrophages in Long COVID. International Journal of Molecular Sciences
The NO Secrets is the part of it you can act on this week.
Also by the McMillans
Both available on Amazon.
Humming Heroes: Inside The Nose That Almost Nobody Knows
John McMillan & Philip McMillan · illustrated by Isil Gül · Lumienta Ltd
A rhyming picture book set inside a child’s nose, where a family of lymphocytes meets an invading microorganism — and humming turns out to matter. Written for children, with the science laid alongside for the adult reading it aloud. The nitric oxide thread starts here.
Disease X: Are You Prepared?
Philip McMillan & John McMillan · illustrated by Isil Gül · Lumienta Ltd
Thirteen chapters on what the COVID years actually taught us about preparedness — from how viruses work to the psychology of a pandemic — written for households rather than for public health departments.
Nitric oxide supports the vascular system. Nothing in this book, or on this page, prevents, treats or cures dementia, COVID-19 or any other condition.
This page is provided for general education. It does not constitute medical advice, diagnosis or treatment, and it does not replace consultation with your own healthcare provider. If you have urgent symptoms, seek emergency medical care.
The NO Secrets is published by Lumienta Limited, London. © 2026 Dr Philip McMillan.
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210 pages · 6 × 9 in
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Both buttons open Lumienta Publishing’s store in a new tab. Lumienta is the McMillan brothers’ publishing partner — it publishes all three of their books, and it is the publisher and sponsor of the weekly VejonMED newsletter. Buying there is buying from the same team behind this page.
Coming soon to Amazon for Kindle readers and countries outside our shipping range